… two antitumor-active trans-oriented complexes, trans-EE and … , trans-[PtCl 2 (E-iminoether)
2 ] (trans-EE) and trans-[PtCl 2 (… a ternary complex trans-[Pt(E-iminoether) 2 (H1 N90 )(DNA)] …

… with significant antitumor activity and, being their DNA-binding … , trans-[PtCl 2 (E-iminoether)
2 ] (trans-EE), trans-[PtCl 2 (NH 3 … The first transformation led to formation of an intermediate …

… therapy also contains some side effects such as diarrhea, liver … anticancer drug was born
in 16th November 1926 and died in 8th … Different types anticancer agents of Pt (II) and Pt (IV) …

… by exposure to various anti-tumor drugs, transition metals, and … -linked to DNA via cisplatin
or trans-[PtCl 2 (E-iminoether) 2 ]. … to antitumor drugs and formed at epigenetic DNA marks, …

… [II]), as one of the principal anticancer chemotherapeutic … obtained on a JEM-2100 transmission
electron microscope at an … (II) in the reducing environment of cells and binding to DNA …

… (Figures 2A, lane 8, and 2C), repair factors were largely lost from DNA (Figure 2B, column
8)… breaks outside of replication or when DPCs are encountered by the transcription machinery. …

… challenges to cell survival by blocking DNA replication, transcription, and repair. However, …
guanine adducts generated by antitumor nitrogen mustards, platinum compounds, 1,2,3,4-…

… In Chapter IV, we investigated the effects of DPCs on transcription using two model DPCs …
form upon exposure to bis-electrophiles such antitumor agents. We found that full-length …

… 1) NER removes DNA lesions that either block the transcription machinery (… treatment with
ICL inducing anticancer agents, or may even help cancerous cells acquire drug resistance. …